IBM's Lotus Notes has the ability to display a popup message when you receive new email. This method only works for email hosted on a Domino Server and uses AMAP Online Internet Mail. If you are not sure whether your email meets this criteria, check with your organization's system administrator.
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In Lotus Notes, select "Preferences" from the File menu.
Expand the Mail option by clicking the "+" next to "Mail."
Select "Check for New Mail Every X Minutes." Set the interval, in minutes, for Notes to check for new mail.
Click "Display a Popup Alert" and click "OK."