IBM's Lotus Notes has the ability to display a popup message when you receive new email. This method only works for email hosted on a Domino Server and uses AMAP Online Internet Mail. If you are not sure whether your email meets this criteria, check with your organization's system administrator.

Set Lotus Notes to notify you with a popup note when you receive an email.
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Step
In Lotus Notes, select "Preferences" from the File menu.
Step
Expand the Mail option by clicking the "+" next to "Mail."
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Step
Select "Check for New Mail Every X Minutes." Set the interval, in minutes, for Notes to check for new mail.
Step
Click "Display a Popup Alert" and click "OK."