Microsoft's Excel program gives users beginner to advanced spreadsheet capabilities. An Excel 2003 worksheet can accommodate up to 256 columns and 65,536 rows of data, while Excel 2007 and 2010 are able to accommodate 16,384 columns and over one million rows of data. Shortcut keys make navigating large worksheets simple, particularly when trying to find the end of the spreadsheet.

Excel 2003
Step
Select "File" from the menu, and choose "Open" from the submenu that appears. Navigate to the folder that contains the file you wish to open. Click on the file and click "Open."
Step
Click on any cell in the worksheet.
Step
Press the "End" key on the keyboard, followed by the "Home" key.
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Excel 2007 and 2010
Step
Click the "Microsoft Office" button in the upper-left corner of the screen. Double-click on the name of the file you wish to open from the menu that appears. If your file is not in the list, click "Open" and navigate to the folder that contains the file. Click on the file and click "Open."
Step
Click on any cell in the worksheet.
Step
Hold down the "Ctrl" key on the keyboard and tap the "End" key.