Computer mice are available that hook either to the mouse serial port or to the USB port on your computer. The simplest way to disable a mouse is to unplug it. However, if you need to free system resources for other tasks, disabling the serial port mouse will require that you disable the driver and possibly the com port. In newer versions of Windows, XP, Windows Vista and Windows System 7, you will need to be the administrator of the computer to disable the mouse.
Click on the "Start" button on your desktop. Choose "Control Panel" from the options.
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Click on "System" on the Control Panel screen. Choose the "Hardware" tab at the top of the screen.
Click on "Device Manager" from the options. Allow the window to populate with the devices on your computer.
Click on the "+" sign next to Mice and other pointing devices in the list.
Click on the installed mouse to highlight the device.
Right-click on the highlighted mouse, and choose "Properties" from the options.
Click on the "General" tab at the top of the window.
Click the drop-down arrow at the bottom of the screen beneath "Device Usage."
Choose "Disable" from the options, and click "OK" at the bottom of the screen.
Use the arrow keys along with the "tab," "shift" and "control" keys to navigate Windows.
The mouse can be enabled again by following the steps and clicking on "Enable" in the drop-down box on the screen.
Most laptops will automatically disable the on-board mouse when an external mouse is plugged in.
Many laptops have a specific mouse configuration program that will allow you to disable the button or the touch pad mouse on the system.