How to Fix Lotus Notes Error: Unable to Initialize VSE Engine
When opening Lotus Notes, it might prompt the following error: "Unable to Initialize VSE Engine." This error is caused by an incompatibility between Lotus Notes and the Notes scanner that ships with VirusScan Enterprise 8.0. Upgrading VirusScan will resolve the issue. If you can't upgrade, then a temporary fix is available, but you should patch your version of VirusScan as soon as possible.
Open the "Start" menu and click "Computer" or "My Computer" depending on your version of Windows. Navigate to the C drive.
Open the "Notes" folder. Double-click on the "Notes.ini" file to open it in Notepad.
Place a semicolon (;) in front of the following two lines to temporarily disable VirusScan:AddInsMenus=NCMenuEXTMGR_ADDINS=NCExtMgr
Click the "Save" option from the "File" menu. Close Notes.ini.